Academic Stuff
Detexify - LaTeX symbol classifier.
Wolfram Alpha - "computational knowledge engine".
The Mathematical Atlas - the various and many areas of maths.
Paul's Online Math Notes - generally good.
Math Overflow - like Yahoo Answers for mathematicians.
gnuplot tips - gnuplot resource.
Circuit Simulator - incredibly cool little thing. (here is code to generate a Chua Circuit, which exhibits chaotic behaviour. Code provided by Metaleer, of ##physics fame.)
Algebraic surfaces gallery - some nice renderings.
Khan Academy - this guy does tutorial videos on many many topics. Unfortunately most of the maths is below JS TP level, but there are others things.
Gravity Simulator - fairly self explanatory.

Comics I Like
A Softer World
Girls with Slingshots
Hark! A Vagrant
Married to the Sea
Nedroid Picture Diary
Questionable Content
Saturday Morning Breakfast Cereal
Stuff No-One Told Me
Three Word Phrase
xkcd

Blogs I Read
Bad Science - Ben Goldacre talking about, well, bad science, largely of the medical kind.
Charlie Brooker column - Amusing rants on current issues.
Cosmic Variance - Sean Carrol etc. talking about science/physics.
Genomes Unzipped - Personal genomics talk.
Gin and Tacos - Somewhat cynical discussion of American politics.
Nature News - I realise this is a link to an RSS feed, but that's how I read it, and this is the free content.

Miscellaneous
How to slice a bagel into two linked halves - self explanatory.
Funny Farm - word (association) puzzle.
Cavalcade of bizarre draw(pudding)s - a page of weird drawings.
ScribblerToo - nice little drawing thing.
Flags of the World - massive flag database.
Animals on the Underground - animals made out of the routes of the London underground.
Vi Hart - snakesnakesnakesnakesnakes. I wish I were as cool as her.

People I Know
Anastasia Ignatyeva
Cathal Ormond
Chris Blair
Cian Booth
David Whyte
Eoin Murphy
Fionn Fitzmaurice
Patrick Conway
Ruairí Short
Ruadhaí Dervan
Shane Duane