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The pattern of genetic hitchhiking under recurrent mutation

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1.	Title	Title of document	The pattern of genetic hitchhiking under recurrent mutation
2.	Creator	Author's name, affiliation, country	Joachim Hermisson; University of Vienna
2.	Creator	Author's name, affiliation, country	Peter Pfaffelhuber; University of Freiburg
3.	Subject	Discipline(s)
3.	Subject	Keyword(s)	Selective sweep, genetic hitchhiking, soft selective sweep, diffusion approximation, Yule process, random background
3.	Subject	Subject classification	92D15 (Primary), 60J80, 60J85, 60K37, 92D10 (Secondary).
4.	Description	Abstract	Genetic hitchhiking describes evolution at a neutral locus that is linked to a selected locus. If a beneficial allele rises to fixation at the selected locus, a characteristic polymorphism pattern (so-called selective sweep) emerges at the neutral locus. The classical model assumes that fixation of the beneficial allele occurs from a single copy of this allele that arises by mutation. However, recent theory (Pennings and Hermisson, 2006a,b) has shown that recurrent beneficial mutation at biologically realistic rates can lead to markedly different polymorphism patterns, so-called soft selective sweeps. We extend an approach that has recently been developed for the classical hitchhiking model (Schweinsberg and Durrett, 2005; Etheridge et al., 2006) to study the recurrent mutation scenario. We show that the genealogy at the neutral locus can be approximated (to leading orders in the selection strength) by a marked Yule process with immigration. Using this formalism, we derive an improved analytical approximation for the expected heterozygosity at the neutral locus at the time of fixation of the beneficial allele.
5.	Publisher	Organizing agency, location
6.	Contributor	Sponsor(s)	WWTF, Vienna; BMBF, Kennzeichen 0313921.
7.	Date	(YYYY-MM-DD)	2008-11-26
8.	Type	Status & genre	Peer-reviewed Article
8.	Type	Type
9.	Format	File format	PDF
10.	Identifier	Uniform Resource Identifier	http://ejp.ejpecp.org/article/view/577
10.	Identifier	Digital Object Identifier	10.1214/EJP.v13-577
11.	Source	Journal/conference title; vol., no. (year)	Electronic Journal of Probability; Vol 13
12.	Language	English=en
14.	Coverage	Geo-spatial location, chronological period, research sample (gender, age, etc.)
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