Electronic Journal of Differential Equations, Vol. 2025 (2025), No. 35, pp. 1-33. Title: Existence and uniqueness of global strong solutions for 3D fractional compressible systems Authors: Mengqian Liu (Donghua Univ., Shanghai, China) Lei Niu (Donghua Univ., Shanghai, China) Zhigang Wu (Donghua Univ., Shanghai, China) Abstract: In this article, we study the Cauchy problem for 3D fractional compressible isentropic generalized Navier-Stokes equations for viscous compressible fluid with one Levy diffusion process. We first obtain the existence and uniqueness of global strong solutions for small initial data by providing several commutators via the Littlewood-Paley theory. We then derive the L^2-decay rate for the highest derivative of the strong solution without decay loss by using a cancellation of a low-medium-frequency quantity. Our results improve those provided recently in [36]. Submitted June 30, 2024. Published April 06, 2025. Math Subject Classifications: 35A09, 35B40;,35Q35. Key Words: Fractional Navier-Stokes equations; global well-posedness; uniqueness; optimal decay rate; Littlewood-Paley theory.