Electronic Journal of Differential Equations, Vol. 2022 (2022), No. 26, pp. 1-15. Title: Boundary-domain integral equations for Dirichlet diffusion problems with non-smooth coefficient Authors: Carlos Fresneda-Portillo (Univ. Loyola Andalucia, Sevilla, Spain) Zenebe W. Woldemicheal (Madda Walabu Univ., Bale Robe, Ethiopia) Abstract: We obtain a system of boundary-domain integral equations (BDIE) equivalent to the Dirichlet problem for the diffusion equation in non-homogeneous media. We use an extended version of the boundary integral method for PDEs with variable coefficients for which a parametrix is required. We generalize existing results for this family of parametrices considering a non-smooth variable coefficient in the PDE and source term in Hs-2(Ω), 1/2< s <3/2 defined on a Lipschitz domain. The main results concern the equivalence between the original BVP and the corresponding BDIE system, as well as the well-posedness of the BDIE system. Submitted May 31, 2021. Published March 04, 2022. Math Subject Classifications: 35J25, 31B10, 45K05, 45A05. Key Words: Non-smooth coefficients; parametrix; Lipschitz domain; diffusion equation; boundary-domain integral equations; minimal wave speed.