Electronic Journal of Differential Equations, Vol. 2022 (2022), No. 15, pp. 1-33. Title: A nonlinear mathematical model for two-phase flow in nanoporous media Authors: Imane Melzi (Ecole Normale Superieure, Kouba, Algiers, Algeria) Youcef Atik (Ecole Normale Superieure, Kouba, Algiers, Algeria) Abstract: We propose a mathematical model for the two-phase flow nanoporous media. Unlike classical models, our model suppose that the rock permeability depends on the gradient of pressure. Using usual laws of flows in porous media, we obtain a system of two nonlinear partial differential equations: the first is elliptic and the second is parabolic degenerate. We study a regularized version of our model, obtained by adding a "vanishing" term to the coefficient causing the degeneracy. We prove the existence of a weak solution of the regularized model. Our approach consists essentially to use the Rothe's method coupled with Galerkin's method. Submitted January 31, 2021. Published February 28, 2022. Math Subject Classifications: 35M32, 76T99, 74F10. Key Words: Nonlinear system; nanoporous media; Rothe's method; Galerkin's method.