Electronic Journal of Differential Equations, Vol. 2021 (2021), No. 39, pp. 1-18. Title: Blow-up criteria and instability of standing waves for the inhomogeneous fractional Schrodinger equation Authors: Binhua Feng (Northwest Normal Univ., Lanzhou, China) Zhiqian He (Qinghai Univ., Xining, China) Jiayin Liu (North Minzu Univ., Yinchuan, China) Abstract: In this article, we study the blow-up and instability of standing waves for the inhomogeneous fractional Schrodinger equation $$ i\partial_tu-(-\Delta)^su+ |x|^{-b}|u|^{p}u=0, $$ where $s\in (\frac{1}{2},1)$, $02-critical and L2-supercritical cases, i.e., $\frac{4s-2b}{N}\leq p< \frac{4s-2b}{N-2s}$, we establish general blow-up criteria for non-radial solutions by using localized virial estimates. Based on these blow-up criteria, we prove the strong instability of standing waves. Submitted November 28, 2020. Published May 07, 2021. Math Subject Classifications: 35B35, 35B40, 35K57, 35Q92, 92C17. Key Words: Inhomogeneous fractional Schrodinger equation; blow-up criteria; strong instability.